Some of the rapid weight regain that occurs when people stop taking GLP-1 medications may be due to the loss of muscle, which reduces metabolism
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Weekly semaglutide at 2.4 mg can achieve weight reductions of 10%12%, while tirzepatide has even demonstrated marked improvement in specific trials, reaching 5%20%+ ( More importantly, cardiovascular and renal outcome studies have demonstrated that GLP-1RAs and related multi-receptor agonists not only lower body weight and blood glucose but also significantly reduce the risk of major adverse cardiovascular events (MACE) and the worsening of renal function
This economic barrier, combined with injection-related concerns, may limit widespread usage
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