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Animal Toxicology Studies Animal toxicology studies tested doses from 0.0027 mg/lb to 9.1 mg/lb via intraperitoneal, intramuscular, intravenous, and oral routes for up to 6 weeks, finding: No acute toxic or lethal dose No gross or histologic toxicity in major organs No hepatotoxicity or nephrotoxicity Negative Ames test (no mutagenicity) Negative chromosomal aberration tests (no genotoxicity) No teratogenicity in rat pregnancy studies No local injection site irritation The LD1 (minimum lethal dose) could not be achieved despite aggressive testing
In medical populations, tesamorelin has been used safely for up to 12 months with manageable side effects
Alcohol abuse can result in impaired testosterone production, shrinkage of the testes, sexual dysfunction, and infertility
Initially, doses are given daily or weekly until levels normalize and maintained monthly afterward
