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These patterns suggest impaired healing capacity rather than insufficient symptom control.or when treatment side effects begin to outweigh benefits

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The combination AZT plus indinavir induced an increase in ROS production, disruption in membrane mitochondrial potential, reduction in intracellular GSH levels, augment permeability of endothelial layer, leading cell death [49]

They observed trimetazidine significantly reduced CRP levels at 6 months from treatment compared to no treatment [117]