GLP-1 drugs (like Ozempic and Mounjaro) are a case study in whats possible when you tackle giant markets that people truly care about
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A question that remains to be answered is whether GSH catabolism occurs primarily in tumours or in non-tumorigenic tissue (for example, kidney)
Whats more, people taking newer medications like tirzepatide were 41% less likely to discontinue than those taking older drugs like liraglutide
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Moreover, compensatory activation of IGF-IR is involved in resistance to co-inhibition of EGFR and MEK in KRAS-mutated colorectal cancer cells [120]