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Insulin-like growth factor 1 (IGF-1), a muscle growth-promoting factor, is mainly produced in liver upon growth factor stimulation [100], or by skeletal muscle cells on androgen stimulation [101]

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The SURMOUNT-1 trial reported that most GI events were mild to moderate, occurred primarily during dose escalation, and decreased in frequency over time

Trial Population69mg/wk Starts at 1 mg and builds slowly through 4 mg before increasing

The above evidence suggests that tanshinone components, especially Tan-IIA, have significant potential in the repair of cerebral microcirculation disorders and neurofunctional restoration in hypoxic environments at high altitudes