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GLP-1s work in a number of ways to bring on weight loss, but their effect on reducing appetite is the major benefit of semaglutide when treating obesity, Kushner says

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The disease is primarily characterized by motor symptoms such as bradykinesia, postural instability, rigidity, and tremor, as well as non-motor symptoms

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There is no official guidance on combining these medications, and concurrent use may cause metabolic conflicts, reduced efficacy of Mounjaro, and increased cardiovascular risks