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In HG-induced MPC5 and STZ-induced SD rat models, placental-derived mesenchymal stem cells (P-MSCs) reduced podocyte damage and increased PINK1/Parkin-mediated mitophagy, providing a certain protective effect on the kidneys [151]

The evolution from Gila monster venom to these diverse medication options demonstrates the remarkable journey of pharmaceutical innovation, transforming a natural toxin into a cornerstone of modern diabetes therapy

SGLT2 Inhibitors Glucose in the bloodstream passes through the kidneys, where it can either be excreted in the urine or reabsorbed back into the blood

doi: 10.1016/j.cjtee.2022.06.002 8

Acid-base balance Maintaining a consistent acid-base balance is critical for optimal pH regulation within the body

injections of 50 mol kg 1 memantine (n = 6 mice and n = 3 cages), 125 mol kg 1 memantine (n = 6 mice and n = 3 cages) or vehicle (isotonic saline, n = 6 mice and n = 3 cages) over 7 days