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"My OB told me to stop at least 8 weeks before trying - semaglutide hangs around for ages, especially if youve been on the higher doses." - u/GlucoseReset "My fertility nurse wanted me off for 3 months before egg collection, just to be safe with anaesthesia and hormones." - u/EmbryoDreaming "I came off at 4mg and waited 10 weeks before trying

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This is because the injections quickly replenish your vitamin stores and support your bodys energy production

For instance, new research presented at ACC.25 in March 2025 indicated that tirzepatide improved kidney function and cardiovascular outcomes in patients with obesity and heart failure with preserved ejection ejection (HFpEF) compared with placebo at one year, showing a 38% lower rate of cardiovascular death or worsening heart failure

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These extended health benefits make GLP-1 therapy a first-line consideration for most patients seeking comprehensive metabolic improvement