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DS-01 with the acrylamideprolinol motif enabled the degradation of pan-KRAS To investigate whether this chemical strategy could be extended to develop degraders against a broad-spectrum of KRAS mutations, we incorporated the acrylamideprolinol motif into a pan-KRAS inhibitor structurally similar to MRTX849 (both developed by Mirati Therapeutics) 66 , successfully designing and synthesizing DS-01 (Fig

Among diverse cell types within the CNS, microglia are distinguished by their remarkable capacity for iron storage and iron accumulation under pathological conditions (36)

YanLReevesPGJohnsonLK.Assessment of selenium bioavailability from naturally produced high-selenium soy foods in selenium-deficient rats

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Their presence in the skin is thought to protect against the damaging effects of actinic irradiation