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The two main approaches are subcutaneous injection (under the skin, typically in the abdominal fat pad) and intramuscular injection (into a muscle belly)

Cartoon schematic of a GST-fusion protein

It is also an excellent ally in the fight against environmental aggressors, protecting the skin from their harmful effects

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The safety profile was broadly consistent with earlier retatrutide studies and the wider incretin drug class, with diarrhoea, nausea and constipation among the most common adverse events