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Key Takeaway: The delivery method is the most important factor for respiratory safety

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Single-particle tracking studies of many membrane-associated receptors suggest that receptors are normally confined in microdomains of the plasma membrane but can hop between these confined areas of the membrane (Daumas et al., 2003

Examples Sitagliptin (Januvia) Dosage Initial: 25100 mg once daily (depending on kidney function) Maximum: 100 mg once daily Saxagliptin (Onglyza) Dosage Initial: 2.55 mg once daily Maximum: 5 mg once daily Linagliptin (Tradjenta) Dosage Initial: 5 mg once daily Maximum: 5 mg once daily Alogliptin (Nesina) Dosage Initial: 6.2525 mg once daily (depending on kidney function) Maximum: 25 mg once daily Possible side effects include: Acute pancreatitis (this appears to be rare) Severe joint pain Thiazolidinediones (TZDs) Primary mechanism(s) of action Modulation of glucose and lipid metabolism via activation of the PPAR-gamma nuclear hormone receptor