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Reactive oxygen species have a causal role in multiple forms of insulin resistance

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On the other hand, traditional treatments often have broader systemic effects and may take longer to show results due to less targeted mechanisms of action

Beyond autophagy, L-ASNase induces mitochondrial dysfunction, triggering apoptosis via calcium dysregulation and ROS-mediated mitochondrial permeability transition pore (mPTP) opening (168)

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