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When combined with levocarnitine, the theoretical benefit is an additive or even synergistic effect on hepatic fat reduction: tirzepatide reduces the caloric load and improves systemic insulin sensitivity, while levocarnitine enhances the liver ability to oxidize existing fat stores and reduce inflammation

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Blood-based and imaging biomarkers not only allow the identification of individuals at risk during prodromal stages but also provide measurable endpoints for clinical trials

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