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Metabolic Factors Your individual metabolism, hormonal balance, sleep quality, stress levels, and underlying health conditions all influence how your body responds to semaglutide

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Withholding is generally only necessary in selected high-risk cases or for patients with significant gastrointestinal symptoms

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Who Should Exercise Extra Caution and When to Consult Your Provider Patients with a history of peptic ulcer disease, gastroesophageal reflux disease (GERD), inflammatory bowel disease, or taking blood thinners should avoid NSAIDs entirely while on semaglutide unless explicitly cleared by their provider