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A genome-wide association study examining common genetic features of AD had identified neuroinflammatory pathways (mainly associated with TNF) to be a key feature of AD, and a driver of risk for these chronic neurodegenerative impairment (121)

Vitamin B12, and vitamin B2 are also important to the function of MTHFR in the folate cycle (Garcia-Minguillan et al, 2014) along with folate

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Glutathione is often referred to as the "master antioxidant" due to its integral role in cellular protection and detoxification