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It should be pointed out that we could not find in the recorded literature any studies that effectively measure sulfur balance in human or other animals

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doi: 10.1016/j.puhe.2025.01.007, 103 TalarK.VetrovskyT.van HarenM.NgyesiJ.GranacherU.VcziM.et al

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Vincent Pedre on this episode of the Take Back Your Health podcast

This pattern suggests continuous daily Dihexa administration beyond 4-6 weeks without rest periods would likely trigger protective receptor downregulation, reducing compound effectiveness over time