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Clinical trials of brand-name semaglutide products like Wegovy and Ozempic did not include b12 supplementation as part of the study protocols

The choice between medications should rest primarily on efficacy data, tolerability, availability, and cost rather than the B12 inclusion, which is valuable in both formulations

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Medical conditions associated with elevated B12: Liver disease: Hepatocellular damage (cirrhosis, hepatitis, hepatocellular carcinoma) releases stored B12 into circulation

Frick's group confirmed, in human cells cultured from lung-tissue biopsies, that the PEN-SP9 conjugate entered the secretory cells and blocked their inflammation-induced mucin secretion

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