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GM3, a sialic acid-containing glycosphingolipid (ganglioside), is predominantly present in the liver, muscle, and plasma of both humans and mice [61]

Elevated ROS also activate the NF-B pathway by depleting glutathione (GSH), downregulating myogenic transcription factors (MyoD, MyoG), and upregulating the transcriptional repressor Yin Yang 1 (YY1), thereby impairing myogenic differentiation (Xiang et al., 2022)