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Furthermore, activation of the kynurenine pathway promotes the production of quinolinic acid, an excitotoxic compound that promotes glutamate release and blocks glutamate reuptake (Steiner et al., 2011

GLP-1 Receptor Agonists: Mechanism and Clinical Profile Comparison GLP-1 agonists (semaglutide, tirzepatide, and others) activate GLP-1 receptors on pancreatic beta cells, intestinal L-cells, and the central nervous system

Diamant M, Van Gaal L, Stranks S, Northrup J, Cao D, Taylor K, et al

Lu SC, Lin SC

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In this regard, the livers of mice which are resistant to the hepatoxic effects of AFB 1 contain high concentrations of a Yc-type GST subunit [55] that has considerable GSH conjugating activity towards AFB 1 -epoxide [34], [37], [10], [9]