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Since low level of endogenous T1 is present in sera of patients affected with chronic inflammatory autoimmune diseases such as psoriatic arthritis, RA and SLE (Pica et al., 2016) as well as in RRMS patients (Giacomini et al., 2017), an interesting approach might also be to quantify the levels of serum T4 in the same categories of patients to investigate whether a deregulation of both these thymic peptides may be related to MS-associated autoimmune responses