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There are biochemical reasons that suggest an intramuscular (IM) injection delivers hydroxocobalamin to the bloodstream more rapidly and potentially more effectively than the subcutaneous (SC) route

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However, many people suffer from Vitamin B12 deficiency due to various reasons, including poor dietary intake, absorption issues, or certain medical conditions

Your doctor will give you a specific time frame for the HCG injections

References NIH PubChem

While we usually think about low B12 causing anemia, a few case reports describe new or worsened polycythemia - an elevated red cell mass - after B12 administration