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While the bone marrow and hematopoietic cells are most affected, other organs involved in hematopoiesis, such as the thymus and spleen, also sustain injury due to IR [64, 65]
96 Activation of these pathways leads to chronic interstitial inflammation and tubular damage, ultimately contributing to kidney fibrosis
External links [edit] Clinical trial number NCT05869903 for "A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-1)" at ClinicalTrials.gov Clinical trial number NCT05872620 for "A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes (ATTAIN-2)" at ClinicalTrials.gov