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The switch to glycolysis led to an increased release of the metabolite lactate, which might be used as an additional source of energy by leukemia cells and confer chemoresistance.34 While MSC are a fundamental component of the BM niche, and contribute to its formation in vivo , other stromal cells may have a role in leukemia maintenance and protection from therapeutic agents

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In wound healing studies, radiolabeled GHK-Cu clears from acute wound sites 3040% faster than from intact skin, likely reflecting increased peptidase expression and protease activity in healing tissue

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