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Following HMGB1 inhibition or 5-HT7R knockout, the downstream Nrf2/xCT/GPX4 signaling pathways was upregulated, resulting in alleviated depressive-like behaviors (Du et al., 2025)

Improvements in insurance coverage and affordability are also contributing to increased patient access

Unlike hormone replacement therapy (HRT), which carries its own risk-benefit profile, GLP-1 compounds work through the appetite and metabolic regulatory system rather than replacing declining estrogen

The most common side effects of GLP-1s are gastrointestinal, such as nausea, vomiting, and constipation

This is typically temporary and resolves within a few days

2131) per United States of America federal government law