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Spironolactone also increases the concentration of lithium (for bipolar disorder) and digoxin (for heart problems), raising the risk of side effects from those drugs

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Severe symptomatic hypoglycemia was defined as an event with symptoms consistent with hypoglycemia requiring the assistance of another person and associated with either a blood glucose below 50 mg/dL (56 mg/dL in the 5-year trial and 36 mg/dL in the ORIGIN trial) or prompt recovery after oral carbohydrate, intravenous glucose or glucagon administration

Researchers are encouraged to verify batch details before commencing laboratory investigations