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This was despite some concerns outlined in briefing documents regarding Lillys trial methodology, including its use of the integrated Alzheimers Disease Rating Scale (iADRS) as the primary endpoint, the use of tau protein levels to decide study inclusion and the cessation of donanemab treatment in patients whose brain amyloid levels dropped past a certain, pre-specified threshold

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"Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants"

De Simone, C., Tzantzoglou, S., Famularo, G., Moretti, S., Paoletti, F., Vullo, V., and Delia, S

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