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132 Advancements in pharmacokinetic optimizationparticularly in enhancing bloodbrain barrier permeabilityare expected to accelerate the transition of these agents from metabolic to neuroprotective indications

Psoriasis and psoriatic arthritis are linked about 30% of people with psoriasis also develop psoriatic arthritis

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Certain patient factors may increase susceptibility to constipation on GLP-1 therapy

doi: 10.1038/s41586-019-1911-y 14 DayEAFordRJSmithBKMohammadi-ShemiraniPMorrowMRGutgesellRMet al

The Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) phase III trials have shown that semaglutide has a strong glycated hemoglobin (HbA 1c )-lowering effect in patients with T2DM when injected subcutaneously once weekly [13,14,15,16,17,18,19]