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In addition, the magnitude of the shear force affects the activation status of neutrophils, and an excessively large shear force can lead to a loss of neutrophil activity and function ( 4.6 NETs NETs are extracellular networks of DNA, histones, microbicidal proteins, and oxidative enzymes that are released by activated neutrophils in response to various stimuli, including viral and inflammatory cytokines (86, 87)

The Phase 2 combination trial in type 2 diabetes reported that, by its 32-week endpoint, the cagrilintide-plus-semaglutide arm reached 15.6% mean weight loss versus 8.1% for cagrilintide alone and 5.1% for semaglutide alone with the combination curve already diverging upward through the early months (Frias et al., 2023)

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Plos One 2013;8:e75927