As a result, many doctors have begun prescribing it not only for diabetes but also for long-term weight management
But, given the drugs daunting prices and supply shortages, many patients are turning to imitationsand those dont always come with the same safety guardrails
Mechanistically, Sodium-glucose cotransporter 2 (SGLT2) inhibitors restore tubuloglomerular feedback, reduce intraglomerular pressure, improve proximal tubular metabolic stress, and are associated with indirect inhibition of pro-inflammatory/pro-fibrotic signaling (such as alleviating interstitial inflammation and oxidative stress), thereby slowing structural progression (Stevens et al., 2024
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