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WT mice)

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Previously unreported effects of RSL3, such as degradation of mTOR signaling pathway protein, p70S6K, and reduction of p-NPM1 levels were identified in the present study and warrant further investigation

The mechanistic rationale builds on earlier work by Kraus and colleagues in Nature (2014), in which adipocyte-specific NNMT knockdown protected mice from diet-induced obesity, establishing NNMT as a metabolic-disease target candidate [2]