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Similarly, dehydroabietic acid ameliorated high-fat diet-induced NAFLD by triggering Nrf2, elevating the levels of GSH, HO-1, and GPX4 for attenuating the accumulation of ROS and lipid peroxide MDA, subsequently suppressing hepatic ferroptosis ( 6 Future directions and perspectives There is growing consensus that the aberrant activation or suppression of ferroptosis is crucial to the pathological progression of numerous liver diseases, making it a promising therapeutic target for the treatment of hepatic disorders
Indeed, some studies have pointed out that this phenomenon may be an important mechanism for developing obesity ( Parasympathetic nerve As another major component of the autonomic nervous system that neutralizes sympathetic activity, and has a complete mediated pathway to the pancreas, the parasympathetic nervous system plays an important role in maintaining metabolic homeostasis, such as maintaining blood sugar ( via an inflammatory response ( Figure 2 )
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