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Central appetite regulatory peptides: receptor classification, peptide, and receptor localization

Semaglutide reduces appetite via brain GLP-1 receptors, slows gastric emptying, and improves insulin sensitivity

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A pilot human safety study with n=2 is far too small to support broad safety claims, and regulatory sources flag concerns about unapproved use, dose uncertainty, impurities, and lack of established therapeutic dosing [10][1516]