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Indeed, the detailed mechanism and regulatory pathways involving receptor phosphorylation [61, 62], -arrestin binding [63, 64], and internalization [20, 65], resensitization and recycling through dephosphorylation [20, 66, 67] may not only be agonist-selective [6769], but also depends on receptor subfamily, cell and tissue types [20, 70, 71]

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The advantage of this design is that it isolates the molecule's direct effect on specific cell types relevant to hair growth

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