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Negative charge increase after HA coating is significantly high, and this could be attributed to carboxylate groups present on the backbone of HA

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Micronutrient status and prediction of disease outcome in adults with inflammatory bowel disease receiving biologic therapy

J., Semba, R

Rev Bras Ginecol Obstet 2024

To overcome these barriers, strategies include functionalizing NPs with BBB-targeting ligands (e.g., transferrin, ApoE-mimetics, mannose-integrated or dual-peptide systems) to enable receptor-mediated transport across the BBB