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Oral administration may produce primarily local gut effects with uncertain systemic reach in humans

some studies suggest it may increase lipid uptake in adipose tissue and decrease lipolysis [53,54], while others suggest GIP may have lipolytic activity, as adipose tissue from transgenic mice overexpressing GIP has been found to be resistant to high-fat feeding [55,56]

It's too late anyway: the company already filed for Food and Drug Administration approval of CagriSema, with a decision expected in late 2026

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Brain 148, 2262-2282