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Significant weight loss may unmask or alter thyroid status, requiring minor levothyroxine dose adjustments

No direct stack RCT has evaluated the combination in humans

In both animal studies and some early human research, activation of this pathway has been associated with reduced food intake and, in some cases, modest weight loss

While more research is still needed, the potential benefits extend far beyond the scale

While some patients may notice a decrease in appetite within a few days of starting the medication, others may take longer to feel its full effects

If your urine is very dark, you likely need more fluids unless a doctor has told you to limit them