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[12] Blundell J, et al

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The heavy chain components are CH1, CH2, CH3, hinge and the VH and light chains consist of CL and the or chains

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The apoptosis involved in SIMI encompasses the activation or inhibition of multiple pathways, including TNF- and MAPK-related, PI3K/AKT/mTOR, and NF-B signaling pathways, with the release of various inflammatory factors that directly lead to myocardial damage, resulting in increased secretion of inducible NO synthase and excessive production of NO (98,104)

The entire treatment takes just a few minutes and can easily be completed during a brief office visit