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In rare cases, it may cause joint pain or muscle stiffness due to increased growth hormone levels

It is approved to reduce excess visceral fat in HIV-associated lipodystrophy , not for general weight loss or cosmetic fat reduction, and the effect reverses when treatment stops

The working principle is as follows: The growth hormone causes the liver to manufacture IGF-1, which then takes charge of many of GHs anabolic effectssuch as encouraging cell growth, protein synthesis, and tissue repair

The antioxidant properties neutralise the free radicals in the body by releasing electrons, which helps prevent cellular damage

In cell or mouse models, blocking ferritinophagy via knockdown of NCOA4 or Atg5, or with the treatment of 3-methyladenine (3-MA), reduces ferritin degradation and iron overload, partially alleviating ferroptosis and ultimately mitigating rifampicin-induced cytotoxicity, liver steatosis and tissue injury

Together they produce a larger, cleaner pulse than either alone