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This validated the in vitro model as representative of age-related Leydig cell dysfunction

Engages cellular senescence pathways: Cellular senescence is characterized by growth arrest and altered gene expression

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Nevertheless, following electrophysiological stimulation, SMAD phosphorylation was dramatically increased (Min et al

Immune-mediated mechanisms - production of autoantibodies to thyroid antigens and lymphocytic thyroid infiltration - are involved in the pathogenesis of AITD