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Analysis of single-cell RNA sequencing Single-cell RNA sequencing (scRNA-seq) data (HRA000425) were downloaded from Genome Sequence Archive (SRA)-Human databases in China National Center for Bioinformation 16 , converted into FASTQ format using fasterq-dump software (sratoolkit 3.0.2, NCBI, NIH, Bethesda, MD, USA), converted into a matrix data file using Cell Ranger software version 3.0.2 (10xGenomics, Pleasanton, CA, USA), converted into Seurat objects using Seurat 5.0.1 software (Satija lab, Lower Manhattan, New York, NY, USA), and plotted for t -distributed stochastic neighbor embedding ( t -SNE) visualization

After mixing each 12 C-labeled sample with an equal volume of the 13 C-labeled pool, the 12 C-/ 13 C- mixtures were injected onto LC-MS for analysis

Notice that the two strongest cells REDEFINE 1 and SURMOUNT-1 are equally well-designed but structurally uncomparable: different sponsors, sites, durations, and comparator arms

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Use in Pregnancy and Lactation Should be used during pregnancy only if clearly needed