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IN DFO in rats resulted in drug concentration in the cortex approximately 10-fold higher than an equivalent intravenous dose, with lower systemic concentrations and systemic side effects (Hanson et al., 2009)

So in ALS, rather than driving pathology, the baseline microbiome might be trying to counteract it, and losing key microbes removes that brake on microglial activation

Williams DM, Staff M, Bain SC, Min T

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iPSCs and ESCs can enter damaged kidneys through systemic delivery via intravenous infusion (236), or local injection (237), as well as through scaffold-based approaches (238), providing potential for transplantation and regenerative therapies