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A randomized, double-blind, placebo-controlled trial in 191 older adults (75 years) with moderate vitamin B 12 deficiency (serum cobalamin concentrations of 107-210 pmol/L) without anemia provided participants with 1 mg/day of cyanocobalamin for one year (94)

As noted, however, the peptide has exhibited minor to no side effects when administered to both animal subjects and humans, across a variety of research settings and dosages

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These findings suggest that FOXO4-DRI has the potential as a therapeutic approach for treating male late-onset hypogonadism