Wu YH, Swaab DF
These properties contribute to its favorable oral absorption, metabolic stability sufficient for once-daily dosing, and tissue distribution compatible with reaching GLP-1 receptors in the pancreas, gastrointestinal tract, and central nervous system
Consistent with the distribution of Firmicutes in the cecal samples, the relative abundance of Ileibacterium was highest in the WD controls (average relative abundance 68%), second highest in the LD controls (average relative abundance 51%), and lowest in the vehicle- and 5A-1MQ-treated mice switched from WD to LD (average relative abundances of 40% and 41%, respectively)
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