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Mechanistically, high-glucose conditions induced robust upregulation of BMP4 and increased phosphorylation of its downstream effectors Smad1/5/9, driving tumorigenic signaling

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As a GLP-1 receptor agonist, it enhances the secretion of insulin, the hormone responsible for regulating blood glucose levels

GLP1-RAs promote insulin secretion while inhibiting glucagon release from the pancreas, leading to glucose-dependent reductions in blood glucose levels

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