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These in vitro studies provide the rationale for a novel approach to optimize antioxidant therapy in ICU patients, namely to use plasma Rlip protein levels to titrate optimal doses of antioxidants

93 A randomized placebo-controlled trial in 50 men with abnormal sperm number, motility, and morphology found 200 mg CoQ10 daily for three months improved sperm parameters and decreased oxidative stress in the seminal fluid

For instance, patients experiencing severe lipid metabolic disturbances may benefit from fatty acid metabolism modulators (135), while those with abnormal glucose metabolism might require insulin therapy or insulin sensitizers (136)

(2025) Cancer, 131: e35732