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Aging cardiomyocytes significantly increase SASP factor expression, including CCN1, ILs (1, 1, and 6), TNF-, MCP-1, TGF-, and GDF15, which are closely associated with age-related cardiovascular dysfunction (Mehdizadeh et al., 2022)

2007 Jul;164(7):1115-7

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Genome wide screens for polymorphisms associated with type 2 diabetes demonstrated that two single nucleotide polymorphisms (SNP) in the TCF7L2 gene were the most frequently occurring SNPs associated with this disease