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XIGDUO XR is not expected to be effective in these populations

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The enhancement of active endogenous GLP-1 leads to increased insulin but reduced glucagon secretion, in addition to delaying gastric emptying and supressing appetite ( Pathophysiology of T2D is characterized by predominant insulin resistance than impaired insulin secretion in Caucasians whereas impaired insulin secretion rather than insulin resistance predominates in Asians ( It is apparent that the therapeutic effects of DPP-IV inhibitors in Asians are more pronounced compared with Caucasians