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This impairment of the bodys self-protective mechanisms prevents effective clearance of ROS, ultimately exacerbating lung damage ( 5.3 Protease-antiprotease imbalance Under physiological conditions, a dynamic balance is maintained between proteases (which degrade tissue components) and antiproteases (which inhibit protease activity) in lung tissue

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GargSMalhotraRKKhanSISarkarSSusruthaPNSinghVet alFisetin attenuates isoproterenol-induced cardiac ischemic injury in vivo by suppressing RAGE/NF-kappaB mediated oxidative stress, apoptosis and inflammation

doi: 10.1038/nri1312 159 LandsL