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Chronic cold stress did not significantly impact body weight or lean mass gain from baseline to endpoint in WT mice, however, led to a significant decrease in fat mass consistent with lower plasma leptin levels (Fig

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Because a large number of comparisons were performed on the relative abundance data, main effect results from these analyses also underwent a BenjaminiHochberg false discovery rate (FDR) correction for multiple comparisons, and instances where a result was significant after this correction have been duly noted