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Excessive growth of pathogenic bacteria increases pro-inflammatory cytokines, thereby exacerbating inflammatory responses and renal pathological injury [86]

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doi: 10.1016/j.mvr.2024.104684 138

Seasonal or Circadian-Based Protocols Aligning with shorter days For older adults whose nighttime melatonin is already low, researchers suggest that timing cycles around late fall or winter (when natural darkness is longer) may reinforce circadian resets. Hardeland, Int J Mol Sci (2012) Adamsson, J Physiol Anthropol (2017) Korkushko, Experimental Gerontology (2004) Reset windows for sleep drift Because short courses modulate melatonin and cortisol, planning a cycle when sleep patterns start breaking downlike earlier wake-ups or fragmented nightsmay help re-anchor circadian health

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Fe 3+ is bond by transferrin (TF) in the plasma and combines with transferrin receptor protein 1 (TFR1) on the cell membrane, facilitating cellular entry via endocytosis